FDA took 684 days to warn meningitis-linked firm: files
















BOSTON (Reuters) – The U.S. Food and Drug Administration took 684 days to issue a warning letter after uncovering infractions that could potentially harm patients at the pharmacy at the center of the deadly U.S. meningitis outbreak, newly released documents show.


The New England Compounding Center (NECC) chastised the FDA in a letter dated January 5, 2007, telling the agency its response time was nearly 18 months longer than the FDA’s average response, according to letters released under an open records request.













“We believe that FDA’s nearly two year delay in issuing the Warning Letter contradicts FDA’s rhetoric regarding the asserted risks associated with our compounded products,” NECC co-owner and chief pharmacist Barry Cadden said in the letter, released by the FDA under an open records request.


The FDA acknowledged in a letter to Cadden dated October 31, 2008, that there had been a “significant delay” in its response but insisted that the delay “in no way diminishes our serious concerns about your firm’s operations.”


On Wednesday, a spokeswoman for the FDA, Erica Jefferson, said the delay in issuing the warning letter was due to the agency’s limited, unclear and contested authority.


“During the time between the inspection of NECC and the issuance of the warning letter, there was ongoing litigation pertaining to pharmacy compounding and significant internal discussion about how to regulate compounders, all of which delayed FDA,” she said.


The FDA has asked lawmakers to clarify its authority to oversee large-scale drug compounders such as NECC. But several Republicans have argued that the agency already had the authority that could have prevented the outbreak.


And on November 19, a congressional panel investigating the outbreak told the FDA not to expect new authority until it releases documents about its role.


According to the Centers for Disease Control and Prevention, 34 people have died and 490 have been injured after Framingham, Massachusetts-based NECC shipped a tainted steroid, methylprednisolone acetate, to medical facilities throughout the United States. The steroid is typically used to ease back pain.


On Tuesday, defense lawyers for NECC’s owners told a U.S. District Judge in Boston there was nothing to show they had a direct hand in the cause of the meningitis outbreak.


INDIGNANT AND UNCOOPERATIVE


NECC has consistently pushed back against attempts by regulators to discipline it, despite a series of violations dating back to 1999.


And the pharmacy’s principals have sometimes shown little respect for the FDA or its inspectors.


During a re-inspection of the pharmacy in 2004 following up on certain marketing and packaging violations, Cadden and his brother-in-law, Gregory Conigliaro, a co-owner of NECC, became indignant, according to a 2005 memorandum from the FDA inspector. Cadden declined to cooperate without speaking to a lawyer first and at one point instructed his brother-in-law not to answer any more questions.


Conigliaro said he had “a lot of things to finish and just did not have the time to sit with us to answer our questions,” the inspector said in his memo.


The FDA’s eventual warning letter to NECC in December 2006 was based on an inspection that began in September 2004 and ended on January 19, 2005, according to the documents.


(Reporting by Tim McLaughlin; Editing by Jeffrey Benkoe and Andre Grenon)


Health News Headlines – Yahoo! News



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Obama praises Netanyahu on Gaza cease-fire

Egypt's Foreign Minister Mohamed Kamel Am, Secretary of State Hillary Clinton and Egypt's President Mohammed Morsi …President Barack Obama praised Israeli Prime Minister Benjamin Netanyahu on Wednesday for agreeing to an Egypt-crafted cease-fire with Palestinian militants in Gaza. Obama, speaking to Netanyahu by telephone, also underlined America's unwavering support for Israel's security and said he hoped to "intensify" U.S. assistance.


"The president commended the prime minister for agreeing to the Egyptian cease-fire proposal—which the president recommended the prime minister do—while reiterating that Israel maintains the right to defend itself," the White House said in a summary of the conversation.


Obama "expressed his appreciation for the prime minister's efforts to work with the new Egyptian government to achieve a sustainable cease-fire and a more durable solution to this problem," the White House said. Netanyahu initiated the call, according to an Obama aide.


The president's press office released the statement to reporters moments into a joint press conference in Cairo where Secretary of State Hillary Clinton and Egyptian Foreign Minister Mohamed Kamel Amr announced the cease-fire.


The emphasis on Egypt's role has been a cornerstone of the American effort ever since Israel answered persistent rocket fire by Gaza's Hamas rulers with punishing airstrikes in a steadily escalating conflict. The country shares a border with Gaza, and President Mohammed Morsi is seen in Washington as someone able to influence the militant Islamist organization's decision-making.


Obama also highlighted American backing of Israel. "The president made clear that no country can be expected to tolerate rocket attacks against civilians," the White House said.


"The president said that the United States would use the opportunity offered by a cease-fire to intensify efforts to help Israel address its security needs, especially the issue of the smuggling of weapons and explosives into Gaza," it said.


"The president said that he was committed to seeking additional funding for Iron Dome and other U.S.-Israel missile defense programs," the White House said.

Read More..

Obama praises Netanyahu on Gaza cease-fire

Egypt's Foreign Minister Mohamed Kamel Am, Secretary of State Hillary Clinton and Egypt's President Mohammed Morsi …President Barack Obama praised Israeli Prime Minister Benjamin Netanyahu on Wednesday for agreeing to an Egypt-crafted cease-fire with Palestinian militants in Gaza. Obama, speaking to Netanyahu by telephone, also underlined America's unwavering support for Israel's security and said he hoped to "intensify" U.S. assistance.


"The president commended the prime minister for agreeing to the Egyptian cease-fire proposal—which the president recommended the prime minister do—while reiterating that Israel maintains the right to defend itself," the White House said in a summary of the conversation.


Obama "expressed his appreciation for the prime minister's efforts to work with the new Egyptian government to achieve a sustainable cease-fire and a more durable solution to this problem," the White House said. Netanyahu initiated the call, according to an Obama aide.


The president's press office released the statement to reporters moments into a joint press conference in Cairo where Secretary of State Hillary Clinton and Egyptian Foreign Minister Mohamed Kamel Amr announced the cease-fire.


The emphasis on Egypt's role has been a cornerstone of the American effort ever since Israel answered persistent rocket fire by Gaza's Hamas rulers with punishing airstrikes in a steadily escalating conflict. The country shares a border with Gaza, and President Mohammed Morsi is seen in Washington as someone able to influence the militant Islamist organization's decision-making.


Obama also highlighted American backing of Israel. "The president made clear that no country can be expected to tolerate rocket attacks against civilians," the White House said.


"The president said that the United States would use the opportunity offered by a cease-fire to intensify efforts to help Israel address its security needs, especially the issue of the smuggling of weapons and explosives into Gaza," it said.


"The president said that he was committed to seeking additional funding for Iron Dome and other U.S.-Israel missile defense programs," the White House said.

Read More..

Greek PM presses for deal on loan
















ATHENS, Greece (AP) — Greece has reacted with dismay to the European Union‘s failure to agree to release vital rescue loan funds for the debt-ridden country, with the prime minister warning it was not just Greece’s future that hangs in the balance.


The delay prolongs uncertainty over the future of Greece, which faces a messy default that would threaten the entire euro currency used by 17 EU nations.













Prime Minister Antonis Samaras stressed that Greece has done what its creditors from the EU and International Monetary Fund required. “Our partners, along with the IMF, also must do what they have committed to doing,” he said.


He said that “it is not just the future of our country, but the stability of the entire eurozone” that depend on the success of negotiations in coming days.


Europe News Headlines – Yahoo! News



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Elmo left behind on ‘Sesame Street’ as actor exits
















NEW YORK (AP) — Even on “Sesame Street,” where everything is famously A-OK, problems can arise for its residents.


And that includes the Muppets. Cookie Monster grapples with an eating disorder. Oscar the Grouch gets cranky. Mr. Snuffleupagus gets the blues.













But Elmo seemed immune to any of that. Since enjoying his breakout success more than two decades ago, the 3 1/2-year-old red monster has radiated good cheer, love and trilling giggles. No wonder everyone — adults as well as children — adores him.


The key to Elmo is “his innocence, his positiveness and his sweetness,” according to Kevin Clash, the man who created him and once told The Associated Press, “I would love to be totally like Elmo.”


Now Clash has been scandalously separated from Elmo and from “Sesame Street,” the TV series where he reigned behind the scenes for 28 years.


Clash spoke of “personal matters” as the cause of his resignation Tuesday after an unthinkable nine-day stretch that began with an unnamed man in his 20s claiming he had sex with Clash at age 16. That allegation was quickly recanted. But then came another accusation of sexual abuse, and a lawsuit.


That second accuser, a 24-year-old college student named Cecil Singleton, said the actor had engaged in sexual behavior with him when he was 15. He is suing Clash for $ 5 million.


“I am deeply sorry to be leaving,” said Clash in his parting statement, “and am looking forward to resolving these personal matters privately.”


But privacy may no longer be possible for Clash, the 52-year-old divorced father of a grown daughter who acknowledged last week that he is gay. Singleton’s lawyer, Jeff Herman, said he has been contacted by two other potential victims of Clash and expects additional legal action.


At a news conference Tuesday, Singleton said he and Clash met on a gay chat line and then, for a two-week period, they engaged in sexual contact, though not intercourse. Sex with a person under 17 is a felony in New York if the perpetrator is 21 or older.


Singleton said he didn’t know Clash’s profession until years later, when he Googled the man’s name.


“I was shocked when I found out what he did for a living,” said Singleton.


Now that career has ended for Clash, who, in his dream job as a puppeteer for “Sesame Street,” was assigned a little-used puppet now known as Elmo, then turned him into a star. In the process, Clash won 23 daytime Emmy awards and one prime-time Emmy. He published his 2006 autobiography, “My Life as a Furry Red Monster,” and was the subject of the 2011 documentary “Being Elmo: A Puppeteer’s Journey.”


Elmo overshadowed Big Bird and other “Sesame” Muppets in popularity and screen time, while marginalizing the cast of live actors. Since 1998, he has had his own show-within-a-show on “Sesame Street” in addition to appearances elsewhere in the hour.


He is also a major moneymaker for Sesame Workshop, the New York-based company that produces the show, and for licensees. At his merchandising height in 1996, he inspired the Tickle Me Elmo doll, which became a cultural phenomenon and that Christmas season’s hottest toy.


This year’s Elmo dolls, “LOL Elmo,” which giggles, and “Let’s Rock! Elmo,” which sings and comes with a microphone and drum set, haven’t made any of this year’s hot toy lists. Even so, Elmo toys probably account for one-half to two-thirds of the $ 75 million in annual sales the “Sesame Street” toy line generates for toy maker Hasbro, estimates BMO Capital Markets analyst Gerrick Johnson.


Johnson said he wasn’t sure how this week’s news might affect sales of Elmo toys this holiday.


“How many people are going to want to explain to their kid why they’re not getting an Elmo?” he asked.


On Tuesday, Hasbro issued a statement saying “We are confident that Elmo will remain an integral part of Sesame Street and that Sesame Street toys will continue to delight children for years to come.”


Despite his resignation, Clash will remain an integral part of “Sesame Street” for the foreseeable future. Taping of season No. 44 will wrap by mid-December and will begin airing next September, according to someone close to the show who spoke on condition of anonymity because the person was not authorized to publicly discuss details of its production. That means new episodes with Clash performing as Elmo will presumably continue well into 2014.


As for who might take over as Elmo, other “Sesame Street” puppeteers were already being trained to serve as Clash’s stand-in, Sesame Workshop said. It’s part of an understudy policy being adopted for all the major Muppet characters.


But no one knows how Elmo will fare going forward. Will the jokes spurred by Clash’s downfall leave a lasting mark on Elmo’s image? Will there be parents who see him tainted by association with the man who brought him to life?


In the wake of a personal tragedy that may still be unfolding, Elmo’s innocence, positiveness and sweetness will be put to the test.


___


AP Television Writer David Bauder and AP Retail Writer Mae Anderson contributed to this report.


Entertainment News Headlines – Yahoo! News



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En los pacientes de Medicare es común que se repitan los tests
















NUEVA YORK (Reuters Health) – La mitad o más de los


beneficiarios de Medicare repiten los tests cardíacos,













pulmonares, estomacales o vesical en tres años, señala un


estudio.


Esas pruebas no deberían repetirse. Es más, en algunos


casos, como el ecocardiograma o la prueba de esfuerzo cardíaco,


existen recomendaciones en contra de su uso rutinario.


“Nos sorprendió la frecuencia con la que se repiten estas


pruebas”, dijo el autor principal, doctor H. Gilbert Welch, del


Instituto para las Políticas de Salud y la Práctica Clínica de


Dartmouth, New Hampshire. “O esos pacientes desarrollan nuevas


enfermedades continuamente o hay médicos que repiten los


estudios como rutina”.


Con su equipo analizó el uso de seis tests en 743.478


beneficiarios de Medicare: ecocardiograma (ultrasonido


cardíaco), prueba de esfuerzo cardíaco, test de función


pulmonar, tomografía de tórax, cistoscopía (exploración de la


vejiga con una sonda) y endoscopía superior (examen el tracto


gastrointestinal superior).


Todas las pruebas eran diagnósticas, es decir que se


realizan en personas con síntomas para que los médicos puedan


realizar un diagnóstico. Cuestan entre 200 y más de 1000


dólares.


En el período 2004-2006, entre el 7 por ciento (cistoscopía)


y el 29 por ciento (ecocardiograma) de los adultos mayores se


habían realizado esos tests por lo menos una vez.


A menudo, esos exámenes se repetían: el 35 por ciento de los


pacientes a quienes se le había indicado una endoscopía del


tracto superior volvió a hacerse la prueba en tres años. Lo


mismo ocurrió con el 55 por ciento que se había realizado un


ecocardiograma. Para el resto de los exámenes, los resultados


estuvieron dentro de ese rango.


El intervalo promedio para la repetición de los tests fue de


entre cuatro y 14 meses, según publica el equipo en Archives of


Internal Medicine.


Welch aclaró que la única excepción médica para repetir


estas pruebas es cuando los pacientes desarrollan un nuevo


conjunto de síntomas que los médicos controlan después de la


primera prueba. Pero los incentivos económicos suelen lograr que


se pidan más exámenes, sin importar la finalidad.


En el caso de un ecocardiograma, por ejemplo, “si es un


cardiólogo quien lo solicita y lo va a interpretar (…) quizás


exista un incentivo económico para sobreutilizar la prueba”,


dijo la doctora Rachel Werner, de University of Pennsylvania,


Filadelfia. “El hecho es que cobramos más por hacer más”,


agregó. Y no siempre es lo mejor.


“Los pacientes comprendieron la importancia de no usar


medicamentos innecesarios. Pero pienso que la noción


generalizada es que un test diagnóstico nunca hará daño”, dijo


Welch. Pero agregó: “Cuando lo realizamos, podríamos distraernos


con un resultado circunstancial”. Son esos resultados los que


exigen nuevas pruebas y, quizás, un tratamiento innecesario.


Su equipo halló también que las ciudades donde se realizaba


la mayor cantidad de pruebas diagnósticas iniciales también


registraban los porcentajes más altos de repetición de esos


tests.


FUENTE: Archives of Internal Medicine, online 19 de


noviembre del 2012.


Seniors/Aging News Headlines – Yahoo! News



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Facebook proposes to end voting on privacy issues
















NEW YORK (AP) — Facebook is proposing to end its practice of letting users vote on changes to its privacy policies. The company says it will continue to let users comment on proposed updates.


The world’s biggest social media company plans to announce Wednesday that its voting mechanism, which is triggered only if enough people comment on proposed changes, has become a system that emphasizes the quantity of responses over the quality of discussion.













Facebook began letting users vote on privacy changes in 2009. Since then, it has gone public and its user base has ballooned from around 200 million to more than 1 billion. As part of the 2009 policy, users’ votes only count if more than 30 percent of all Facebook’s active users partake.


Social Media News Headlines – Yahoo! News



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AP Exclusive: Syrian rebels seize base, arms trove
















BASE OF THE 46TH REGIMENT, Syria (AP) — After a nearly two-month siege, Syrian rebels overwhelmed a large military base in the north of the country and made off with tanks, armored vehicles and truckloads of munitions that rebel leaders say will give them a boost in the fight against President Bashar Assad‘s army.


The rebel capture of the base of the Syrian army’s 46th Regiment is a sharp blow to the government’s efforts to roll back rebels gains and shows a rising level of organization among opposition forces.













More important than the base’s fall, however, are the weapons the rebels found inside.


At a rebel base where the much of the haul was taken after the weekend victory, rebel fighters unloaded half a dozen large trucks piled high with green boxes full of mortars, artillery shells, rockets and rifles taken from the base. Parked nearby were five tanks, two armored vehicles, two rocket launchers and two heavy-caliber artillery cannons.


Around 20 Syrian soldiers captured in the battle were put to work carrying munitions boxes, barefoot and stripped to the waist. Rebels refused to let reporters talk to them or see where they were being held.


“There has never been a battle before with this much booty,” said Gen. Ahmad al-Faj of the rebels Joint Command, a grouping of rebel brigades that was involved in the siege. Speaking on Monday at the rebel base, set up in a former customs office at Syria’s Bab al-Hawa border crossing with Turkey, he said the haul would be distributed among the brigades.


For months, Syria’s rebels have gradually been destroying government checkpoints and taking over towns in the northern provinces of Idlib and Aleppo along the Turkish border.


Rebel fighters say that weapons seized in such battles have been essential to their transformation from ragtag brigades into forces capable of challenging Assad’s professional army. Cross-border arms smuggling from Turkey and Iraq has also played a role, although the most common complaint among rebel fighters is that they lack ammunition and heavy weapons, munitions and anti-aircraft weapons to fight Assad’s air force.


It is unclear how many government bases the rebels have overrun during the 20-month conflict, mostly because they rarely try to hold captured facilities. Staying in the captured bases would make them sitting ducks for regime airstrikes.


“Their strategy is to hit and run,” said Elias Hanna, a retired Lebanese army general and Beirut-based strategic analyst. “They’re trying to hurt the regime where it hurts by bisecting and compartmentalizing Syria in order to dilute the regime’s power.”


The 46th Regiment was a major pillar of the government’s force near the northern city of Aleppo, Syria’s economic hub, and its fall cuts a major supply line to the regime’s army, Hanna said. Government forces have been battling rebels for months over control of Aleppo.


“It’s a tactical turning point that may lead to a strategic shift,” he said.


At the 46th Regiment’s base, about 25 kilometers (15 miles) west of Aleppo, the main three-story command building showed signs of the battle — its walls punctured apparently from rebel rocket attacks. The smaller barracks buildings scattered around the compound, about 2.6 square kilometers (1 square mile) in size, had been looted, with mattresses overturned. A number of buildings had been torched.


Reporters from The Associated Press who visited the base late Monday saw no trace of the government troops who had been defending it — other than the dead bodies of seven soldiers.


Two of them, in camouflage uniforms, lay outside the command building. One of them was missing his head, apparently blown off in an explosion.


The rest were in a nearby clinic. Four dead soldiers were on stretchers set on the floor, one with a large gash in his arm, another with what appeared to be a large shrapnel hole in the back of his head. The last lay on a gurney in another room, his arms and legs bandaged, a bullet hole in his cheek and a splatter of blood on the wall and ceiling behind him as if he had been shot where he lay.


It could not be determined how or when the soldiers had been killed.


The final assault that took the base came after more than 50 days of siege that left the soldiers inside demoralized, according to fighters who took part.


Working together and communicating by radio, a number of different rebels groups divided up the area surrounding the base and each cut the regime’s supply lines, said Abdullah Qadi, a rebel field commander. Over the course of the siege, dozens of soldiers defected, some telling the rebels that those inside were short of food, Qadi said.


The rebels decided to attack Saturday afternoon when they felt the soldiers inside were weak and the rebels had enough ammunition to finish the battle, Qadi said. The battle was over by nightfall on Sunday. Seven rebel fighters were killed in the battle, said al-Faj of the rebels’ Joint Command. Other rebel leaders gave similar numbers.


It remains unclear how many soldiers remained in the base when the rebels launched their attack and what happened to them.


Al-Faj said all soldiers inside were either killed or captured. He said he didn’t know how many were killed, but that the rebels had taken about 50 prisoners, all of whom would be tried in a rebel court. Aside from the 20 prisoners seen at the rebel’s Bab al-Hawa base, the AP was unable to see any other captured soldiers.


The Syrian government does not respond to requests for comment on military affairs and said nothing about the base’s capture. It says the rebels are terrorists backed by foreign powers that seek to destroy the country.


Disorganization has plagued the Syrian opposition since the start of the anti-Assad uprising in March 2011, with exile groups pleading for international help even when they have no control over those fighting inside of Syria.


A newly formed Syrian opposition coalition received a boost Tuesday, when Britain officially recognized it as the sole representative of the Syrian people.


The National Coalition of the Syrian Revolutionary and Opposition Forces was formed in the Gulf nation of Qatar on Oct. 11 under pressure from the United States for a stronger, more united opposition body to serve as a counterweight to more extremist forces.


British Foreign Secretary William Hague said Tuesday the body’s members gave assurances to be a “moderate political force committed to democracy” and that the West must “support them and deny space to extremist groups.”


The United States and the European Union have both spoken well of the body but stopped short of offering it full recognition.


Key to the body’s success will be its ability to build ties with the disparate rebel groups fighting inside Syria. Many rebel leaders say they don’t recognize the new body, and a group of extremist Islamist factions on Monday rejected it, announcing that they had formed an “Islamic state” in Aleppo.


Anti-regime activists say nearly 40,000 people have been killed since Syria’s crisis started 20 months ago.


___


Associated Press write Elizabeth Kennedy contributed reporting from Beirut, Lebanon.


Middle East News Headlines – Yahoo! News



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Nintendo’s Wii U: First Impressions
















GamePad


The Wii U GamePad has a 6.2-inch touchscreen.


Click here to view this gallery.













[More from Mashable: Meet the Super Fan Who Waited in Line for a Month for a Wii U [VIDEO]]


Nintendo‘s newest console has only been available for one day, but that’s still enough time for early-bird consumers to get their hands on the Wii U, and test out its features and games.


We spent the last 24 hours playing with the Wii U, and have organized our early thoughts on the system. Read on if you’re on the fence about buying one.


[More from Mashable: Toys ‘R’ Us Says Wii U Pre-Order Shipments May Be Delayed]


Out of the Box


Setting up the Wii U is easy, but installing the software is more of a process. Nintendo issued a day-one patch to activate features such as MiiVerse, the company’s social features; this means users will spend between one to three hours (depending on connection speed) downloading and installing a patch that bricks their system. Not a great way to greet consumers excited to play your games. But there’s a chance that servers won’t be as busy in the coming weeks, so download times may improve. Each game I inserted had its own patch too, which users have to install on the second playthrough.


After getting through the patch, user still face an involved setup. They have to create their Mii avatar before they start playing, and create a Nintendo Network ID for network play. Users must also set up the GamePad’s universal remote functionality, which is thankfully the easiest part of the process. They only have to pick their TV manufacturer (the Wii U knows what to do next). The GamePad controls volume, input source and channels.


Look and Feel


The GamePad is the Wii U’s main portal, so users need it to access all the relevant menus (the console shows a different menu from the television); here, users can launch applications by touch. The default view includes apps such as Netflix, Hulu Plus, Amazon Video Services and YouTube; but only Netflix is available now, which seems a bit like false advertising. Loading other options, such as the Nintendo eShop, requires pressing the Home button on the controller, which is unintuitive at first. But soon, the button quickly becomes a handy way to navigate to other parts of the Wii U, like the upcoming Nintendo TVii.


The most troublesome thing about the console is that everything moved slowly; launching games and apps took a long time. I felt like I spent awhile looking at a spinning blue circle.


Wii U games definitely take advantage of the console’s ability to support high-definition graphics. Cartoony games, such as Scribblenauts Unlimited or Nintendo Land look beautiful. For games such as ZombiU, which are supposed to appear more realistic, users might be disappointed. This system is supposed to be the next-generation of gaming consoles — meant to outshine the Xbox 360 — but I can’t say it achieves that.


The GamePad


Pre-launch, Nintendo has spent much of its time crowing about the features of the GamePad, a hybrid touch screen and controller that’s central to the Wii U. The first thing I noticed is its large size; but after spending a few hours with the GamePad, I’ve concluded that it won’t weigh you down like an iPad, yet is substantial enough that it doesn’t feel like a toy (though the glossy finish makes it look like one.)


Unfortunately, the GamePad takes some getting used to as an actual controller, especially for games that require more than simple controls or the gyroscope. My biggest complaint is that Nintendo bucked all gaming-controller tradition by swapping the position of the right analog stick and the four letter buttons. Anyone who has played any other modern console (including Nintendo’s own GameCube) knows instinctively that the analog stick goes below the buttons; but Nintendo flipped them on both the GamePad and the Pro Controller. If the company is only targeting non-gamers, they won’t notice; but this will be a difficult change for many others. Despite this drawback, the buttons, and especially triggers, feel good.


The GamePad is mostly dominated by the 6.2-inch touch screen with a passable resolution: 854 x 480. The most appealing feature of the Wii U — that users can play games or watch movies entirely on the GamePad — may be spoiled for some looking for HD crispness. Still, I watched a whole episode of Portlandia from Netflix on the GamePad, and also spent time playing New Super Mario Bros. U with the television off. Being able to isolate your gameplay to a smaller screen is very novel, and one of my favorite parts of the system.


Games


Nintendo’s Wii U has a better launch lineup coming out, compared to other consoles — but only a few titles stick out. Almost everyone I talked to in line at the Nintendo World store during the Wii U launch wanted New Super Mario Bros. U or ZombiU, both of which are fun titles. Nintendo Land, which is a pack-in if users purchase the Deluxe model, is going to be a huge hit at parties; from what I’ve seen so far, it has some engrossing minigames. I haven’t cracked open Scribblenauts Unlimited yet, but in demos it looks like a very promising title that would go well with a touch screen.


Some non-exclusive titles on other consoles are also appealing. I’m looking forward to digging in to Epic Mickey 2 and Tekken Tag Tournament 2. While the system had 24 launch titles, many more are expected to debut in the coming months.


I plan to spend Thanksgiving week exploring the Wii U, and will write a more detailed report on whether it’s the right console for gamers, families or casual users.


This story originally published on Mashable here.


Gaming News Headlines – Yahoo! News



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“Twilight” sendoff starts with huge $341 million worldwide
















(Reuters) – The “Twilight” vampire saga‘s final chapter debuted with a massive $ 341 million in global movie ticket sales as devoted fans bid farewell to blood-sucking spouses Bella and Edward and one of Hollywood‘s biggest franchises.


“The Twilight Saga: Breaking Dawn – Part 2″ earned an estimated $ 141 million in the United States and Canada over the weekend, falling slightly short of a record for the supernatural romance series about a human-vampire-werewolf love triangle.













The total, which includes sales from late night Thursday through Sunday, ranked as the eight biggest domestic film debut of all time. Late-night Thursday screenings comprised $ 30.4 million of the $ 141 million total.


Fan fever for the fifth “Twilight” movie raged high around the world. “Breaking Dawn – Part 2″ rang up sales of $ 199.6 million from Thursday to Sunday at theaters in 61 countries for a worldwide total of $ 341 million, distributor Summit Entertainment said on Sunday.


The earlier “Twilight” films pulled in a combined $ 2.5 billion at global box offices over a four-year run. The success lifted tiny studio Summit Entertainment into Hollywood‘s big leagues and paved the way for its $ 412 million acquisition in January by Lions Gate Entertainment.


“New Moon” scored the biggest debut of the series, grossing $ 142.8 million over its first three days in 2009.


The movies based on a series of best-selling young adult books by Stephenie Meyer ignited a pop culture infatuation with blood-sucking vampires and werewolves. The films star Kristen Stewart as human-turned-vampire Bella Swan, Robert Pattinson as her vampire love Edward Cullen, and Taylor Lautner as werewolf Jacob Black, who competes for Bella’s affection.


Summit spent $ 120 million to produce “Breaking Dawn – Part 2,” which concludes the tale with newly turned vampire Bella and husband Edward in a high-stakes battle to protect their half-human, half-vampire daughter from an ancient vampire clan. The couple enlist the extended Cullen family in their fight.


Fans of the series, mostly teen girls nicknamed “Twi-hards,” embraced the final film, which includes a surprise twist that was not in the final book. Audiences polled by CinemaScore awarded the movie an “A” grade, with an “A+” from filmgoers under age 25, according to Summit. Critics were less supportive. Fifty-one percent of reviews collected on the Rotten Tomatoes website were positive.


Summit Entertainment‘s president of domestic distribution Richie Fay said though the vast majority of the audience was female, he expected more male viewers than for previous “Twilight” films.


“The male audience has increased a good bit, and the ratings among males are higher I think in part to the action in the film,” he said.


Author Meyer has not ruled out the possibility of more stories in the vampire-werewolf universe but said she has closed the chapter on the Cullens.


Hollywood is eager to fill the void after the success of “Twilight” highlighted the power of young adult stories on the big screen. Studios are bringing at least four new films based on popular young adult novels to theaters next year as well as the sequel to the newest teen movie sensation, “The Hunger Games.


The “Twilight” excitement eclipsed all other movies over the weekend. Last week’s winner, James Bond movie “Skyfall” finished in second place with $ 41.5 million at North American (U.S. and Canadian) theaters.


“Skyfall” is now the highest-grossing Bond movie to date with a global total of over $ 669 million, surpassing the $ 599 million taken in by “Casino Royale” in 2006.


“Skyfall” also propelled distributer Sony Pictures Entertainment to a record year, pushing its worldwide box office total over the $ 4 billion mark.


Historical drama “Lincoln” expanded from a limited opening a week ago and landed in third place with $ 21 million. The movie stars Daniel Day-Lewis as the 16th president near the end of his life as he battles to ban slavery and end the Civil War. The movie is directed by Steven Spielberg and has earned critical praise and awards-season buzz.


In fourth place, Walt Disney Co animated movie “Wreck-It Ralph,” about a videogame character who destroys everything in his path, pulled in $ 18.3 million. Denzel Washington drama “Flight” earned $ 8.6 million and the No. 5 spot.


Elsewhere, romantic comedy “Silver Linings Playbook” brought in $ 458,000 at 16 locations, or an average of $ 28,625 per theater. The film stars Bradley Cooper as a bipolar former teacher just released from a mental institution and Jennifer Lawrence as a young widow he encounters as he tries to put his life back together.


“Silver Linings” won over critics who say it may earn a spot in the Oscar race. The Weinstein Co, the private company that released the movie, will expand the film nationwide beginning on Wednesday, November 21.


Sony Corp’s movie studio distributed “Skyfall.” “Lincoln” was produced by Dreamworks and released by Walt Disney Co. “Flight” was distributed by Paramount Pictures, a unit of Viacom Inc.


(Reporting by Lisa Richwine; Editing by Jackie Frank)


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