New Genetic Tests Determines Breast Cancer and Ovarian Cancer Risks






COMMENTARY | New research has uncovered that mutations in the PPM1D gene is associated with an increased risk of breast cancer and ovarian cancer. Unlike BRCA1 and BRCA2 mutations, the PPM1D mutation is not inherited. Instead, the mutation only shows up in the blood when breast cancer or ovarian cancer is present. Medical News Today quotes professor Nazneen Raham as saying, “This is one of our most interesting and exciting discoveries.”


Important discovery






PPM1D mutations are very important. Because of the way they show up in the blood, if you have this mutation you have a 1 in 5 chance of developing breast cancer or ovarian cancer. That is almost twice the average risk for breast cancer and it is 10 times the risk for ovarian cancer. Knowing if you carry this mutation will help women decide on imaging and other preventative treatments. Right now, the only genetic test we have is the BRCA test. As PPM1D shows, BRCA is not the only gene mutation that indicates and increased risk for breast or ovarian cancers.


The study


Unlike many recent studies that have so few participants it makes the data questionable, this study looked at 7,781 women with either breast cancer or ovarian cancer and compared the PPM1D gene to 5,861 women from the general population. This allows the results to be statistically significant because they looked at so many different results. What the study showed is that in the group of women who had cancer, the researchers found 25 faults in the PPM1D gene. In the group of women without cancer only one fault was found. From a statistical standpoint, those results are quite amazing.


This study proves that newer, more detailed gene sequencing is needed to help determine cancer risks. This is especially true for ovarian cancers, sometimes called the silent killer, because most times this type of cancer is not caught until very late stages. Women with a family history of breast cancer or ovarian cancer need more weapons for detection in their arsenal. BRCA testing alone does not cut it. In my case, I have a family history of cancer but no identified genetic issues, like BRCA. I wonder how many lives testing for PPM1D could save.


Lynda Altman was diagnosed with breast cancer in November 2011. She writes a series for Yahoo! Shine called “My battle with breast cancer.”


Health News Headlines – Yahoo! News





Title Post: New Genetic Tests Determines Breast Cancer and Ovarian Cancer Risks
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

British retailers start online sales early






LONDON (Reuters) – British retailers have brought forward their Christmas clearance sales online in the hope that shoppers will log on to buy bargains and offset lackluster spending in stores.


Marks & Spencer launched its sale online at midday on Monday, it said on its website, while department store John Lewis said it would cut online prices when its stores close at 1700 GMT. Debenhams has already started its online sale.






Retailers in recent years have started sales online on Christmas Day, ahead of the clearances in stores from Boxing Day, but are increasingly launching their online offers before Christmas after delivery deadlines for the day have passed.


Hard-pressed shoppers have been leaving it later to buy presents in the hope that retailers would slash prices, the British Retail Consortium said.


It was forecasting that 5 billion pounds ($ 8.1 billion) would be spent in the shops on Saturday and Sunday combined, the last weekend before Christmas.


Richard Dodd, the BRC’s head of Media and Campaigns, said weekend trading had met expectations.


Christmas, ultimately once all the final sums are done, will turn out to be acceptable but not exceptional,” he said.


He said the sector expected a modest increase in cash spending against a year go, but not necessarily any significant increase in real terms once inflation was stripped out.


Many British families‘ budgets are stretched, according to a survey from Markit that showed the biggest deterioration in household finances for seven months.


Analyst Howard Archer at IHS Global Insight said the weakening in household finances could not come at a worse time for retailers, and it highlighted why many people appeared to have been careful in their Christmas shopping this year.


“The suspicion has to be that consumers will be especially keen to take advantage of genuine major bargains in the sales to acquire items that they cannot otherwise afford or are reluctant to make at the moment,” he said.


“However, we suspect that people will likely to be more careful in buying – or reluctant to buy – items that they don’t really want or need in the sales.”


($ 1 = 0.6180 British pounds)


(Reporting by Paul Sandle; Editing by Louise Heavens)


Internet News Headlines – Yahoo! News





Title Post: British retailers start online sales early
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Syria jets kill tens as international envoy visits






BEIRUT (AP) — A government airstrike on a bakery in a rebel-held town in central Syria killed more than 60 people on Sunday, activists said, casting a pall over a visit by the international envoy charged with negotiating an end to the country’s civil war.


The strike on the town of Halfaya left scattered bodies and debris up and down a street, and more than a dozen dead and wounded were trapped in tangled heap of dirt and rubble.






The attack appeared to be the government response to a newly announced rebel offensive seeking to drive the Syrian army from a constellation of towns and village north of the central city of Hama. Halfaya was the first of the area’s towns to be “liberated” by rebel fighters, and activists saw Sunday’s attack as payback.


“Halfaya was the first and biggest victory in the Hama countryside,” said Hama activist Mousab Alhamadee via Skype. “That’s why the regime is punishing them in this way.”


The total death toll remained unclear, but the Britain-based Syrian Observatory for Human Rights said more than 60 people were killed. That number is expected to rise, it said, because some 50 of those wounded in the strike are in critical condition.


Amateur videos posted online Sunday showed residents and armed rebels rushing to the scene. One stopped to cover a mound of human flesh lying in the street with his coat.


More than a dozen dead or seriously wounded people lay in the street near a simple, concrete building, some in puddles of blood. Near its front wall, bodies jutted from a pile of dirt and rubble on the sidewalk.


Rebels screamed in distress while trying to extract the bodies, while others carried away the wounded.


It was unclear from the videos if the building was indeed a bakery. Nearly all the dead and wounded appeared to be men, some wore camouflage, raising the possibility that the jet had targeted a rebel gathering.


For the past week, rebels have been launching attacks in the area, most notably in the nearby village of Morek, where they hope to seize control of the country’s main north-south highway, preventing the regime from getting supplies to its forces further north in the provinces of Idlib and Aleppo.


On Saturday, one rebel group threatened to storm two predominantly Christian towns nearby if their residents did not “evict” government troops they said were using them as a base to attack nearby areas.


The activist accounts could not be independently verified due to restrictions on reporting in Syria. The Syrian government does not respond to requests for comment on its military activities.


The attack coincided with the start of a two-day visit by Lakhdar Barhimi, who represents the U.N. And the Arab League, to meet with top Syrian officials.


Brahimi has made little apparent progress toward ending Syria’s crisis since assuming his post in September, mostly because the sides appear more interested in fighting it out than in sitting down for talks.


Brahimi did not speak publicly upon arriving in Damascus for a two-day mission, and it was unclear whether he would present new ideas to end the war. His trip appeared troubled from the start.


Instead of flying directly to Syria as he had on previous visits, Brahimi landed in Beirut and traveled to the Syrian capital by land because of fighting near the Damascus airport, Lebanese officials said.


The Lebanese officials, who spoke on condition of anonymity because they were not authorized to brief reporters, said Brahimi was expected to meet Syria’s foreign minister later Sunday and President Bashar Assad on Monday.


The trip is Brahimi’s third since taking the job following the resignation of former U.N. Secretary General Kofi Annan after both sides disregarded a cease-fire he brokered in April.


While not advancing a comprehensive peace plan, Brahimi has called on the sides to negotiate a solution.


The security situation has gotten notably worse for the regime since his last visit, with rebels storming a number of military bases and seizing valuable munitions. Russia, Assad’s most powerful international backer, also appears to have changed his assessment of Assad’s strength, as top officials say they do not seek to preserve his regime, while still calling for a negotiated solution.


Still, neither side appears willing to talk.


In a lengthy Sunday news conference, Syrian Information Minister Omran al-Zoubi repeated the Syrian government’s line that it is fighting terrorist groups backed by foreign powers who seek to destroy Syria.


Al-Zoubi said the government was willing to engage in dialogue but said the other side wasn’t.


“We speak of dialogue with those who believe in national dialogue,” he said. “But those who rejected dialogue in their statements and called for arms and use of weapons, that’s a different issue. They don’t want dialogue.”


Rebel groups refuse to talk to Assad, saying too many people have died for him to be considered part of the solution.


Violence raged elsewhere in the country on Sunday. Anti-regime activists reported government airstrikes on suburbs east of the capital and the northern province of Aleppo.


Airstrikes on the town of al-Safira, south of Aleppo, killed 13 people, including a mother and five daughters from one family, a local activist named Hussein said via Skype. He gave only his first name for fear of retribution.


The town lies next to a large military complex with factories and artillery and air defense bases. Hussein guessed the airstrike was payback for recent rebel attacks on the complex.


“The strikes don’t hit the fighters at all,” he said. “They want to take revenge on the civilians.”


The Observatory said at least 10 rebels and an unknown number of government troops were killed in clashes in Afreen, near Aleppo, Syria’s largest city, as rebels sought to storm an army base there.


Anti-regime activists say more than 40,000 people have been killed since Syria’s crisis began in March 2011.


___


Associated Press writer Albert Aji contributed reporting from Damascus.


Middle East News Headlines – Yahoo! News





Title Post: Syria jets kill tens as international envoy visits
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Top Comments: Mashable Readers React to Instagram’s Terms of Service






Monday, Dec. 17: Instagram Updates TOS


Readers had varying reactions to Instagram‘s updates. Some felt that they were fair: If you don’t like the terms of service, argued some users, you have the option not to use the service. Others were far more outraged.


Click here to view this gallery.






[More from Mashable: Why xkcd Is Wrong About Instagram]


This week, the top comments on Mashable brought into focus both the state of the world around us and the constantly changing nature of our virtual lives. Our readers launched into debate when Instagram appeared to be making drastic changes to its privacy policy. Based on the wording of Instagram’s new Terms of Service, photographers worried that they may no longer own the rights to their own work, and that their photos could be used in advertising. As Mashable‘s Chris Taylor put it, the TOS as they stood early this week basically “signed your life away.”


Over the course of the week, we saw new privacy settings for Instagram users revealed, officially commented upon (while remaining unchanged) and then finally rescinded and apologized for.


[More from Mashable: Instagram Updates Its Terms of Service Based on User Feedback]


The Instagram controversy proved that users are, in fact, paying attention to the often glossed-over Terms of Service established by their favorite apps, and that a company’s response to public outcry has the potential to make or break their service.


Mashable‘s senior tech analyst, Christina Warren, compared Instagram’s actions to Netflix’s in the summer of 2011. Outraged users proved they weren’t bluffing about abandoning Instagram: Celebrities and power users threatened to quit the network, and downloads of rival apps such as Flickr and Aviary soared in the days surrounding the controversy. What was your take on this week’s events, involving photo-sharing and users’ right to ownership?


Even more commented upon, though less debated, were two Mashable stories that examined social media backlash in the wake of a tragedy. In the days following the horrific shooting at Sandy Hook Elementary in Newtown, Connecticut, we found ourselves contemplating, both online and off, the horrific nature of the event. Unsurprisingly, the two most-commented-upon stories this week both centered on Sandy Hook’s impact on the social web. Our commenters sounded off on the offensive tweets sent during Obama’s Newtown speech, as well as on the viral post, “I Am Adam Lanza’s Mother.”


Other stories our commenters flocked to this week included a viral video of a golden eagle snatching a baby (later proved to be a hoax), the hacking of the Westboro Baptist Church by hacktivist group Anonymous and the appalling revelation that Facebook’s interns make more money than all of us. We also prepared for the end of the world as brought forth by the Mayan Apocalypse — which never did happen.


What were your favorite moments on Mashable this week? You can be part of the discussion by signing up with one of your social networks, and joining the conversation on our site. Next week, your voice could be featured in the Top Comments.


Happy holidays to our community!


Image courtesy of flickr, Marc Wathieu


This story originally published on Mashable here.


Tech News Headlines – Yahoo! News





Title Post: Top Comments: Mashable Readers React to Instagram’s Terms of Service
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

South Africa’s Mandela responding to treatment in hospital






JOHANNESBURG (Reuters) – Former South African president and anti-apartheid hero Nelson Mandela, who is 94, continues to respond to treatment two weeks after being taken to hospital, the government said on Saturday.


The Nobel Peace laureate, who has been treated for a lung infection and gallstones after being hospitalized on December 8, was visited by South African President Jacob Zuma, presidency spokesman Mac Maharaj said in a statement.






“Madiba has been in hospital since the 8th of December and continues to respond to treatment,” Maharaj said, referring to Mandela by his clan name.


President Zuma assured him of the love and support of all South Africans, young and old, and the whole world.”


The country’s first black president was admitted to hospital in Pretoria earlier this month after being flown from his home village of Qunu in a remote part of the Eastern Cape province.


It seems likely that Mandela, admired at home and abroad as a global icon against injustice for his lifetime of struggle against minority white rule, will end up spending Christmas in the hospital.


On Thursday, following his re-election as leader of the ruling African National Congress (ANC), Zuma reported Mandela had “steadily improved”.


Zuma said then the former president was receiving “the best care possible” but recalled that Mandela was “at an age where medical challenges require extraordinary care”.


He praised Mandela as an “unparalleled fighter”.


In an interview broadcast on Saturday but recorded a day earlier, the ANC’s newly elected Deputy President Cyril Ramaphosa said he believed Mandela was “on the mend”.


Mandela spent 27 years in apartheid prisons, including 18 years on the windswept Robben Island off Cape Town. He was released in 1990 and went on to use his prestige to push for reconciliation between whites and blacks as the bedrock of the post-apartheid “Rainbow Nation”.


He stepped down in 1999 after one term in office and has been largely removed from public life for the last decade.


Mandela spent time in a Johannesburg hospital in 2011 with a respiratory condition, and again in February this year because of abdominal pains. He was released the following day after a keyhole examination showed there was nothing serious.


He has since spent most of his time in Qunu.


His fragile health prevents him from making any public appearances in South Africa, although he has continued to receive high-profile domestic and international visitors, including former U.S. president Bill Clinton in July.


(Reporting by David Dolan; Editing by Pascal Fletcher)


Celebrity News Headlines – Yahoo! News





Title Post: South Africa’s Mandela responding to treatment in hospital
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Former President George H.W. Bush remains hospitalized






(Reuters) – Former President George H.W. Bush, who has been hospitalized for a month undergoing treatment for bronchitis, may not be released from a Houston hospital in time to celebrate Christmas at home as doctors had hoped.


Bush, 88, remained in stable condition and doctors were optimistic he would make a full recovery, George Kovacik, a spokesman at Methodist Hospital, said in an emailed statement on Sunday.






But doctors were being “extra cautious” with his care and no discharge date had been set, the statement said. Earlier this month, Kovacik said doctors expected Bush would be able to spend Christmas at home with his family.


“His doctors feel he should build up his energy before going home,” the statement said.


Bush, the 41st president and a Republican, took office in 1989 and served one term in the White House. The father of former President George W. Bush, he also is a former congressman, U.N. ambassador, CIA director and vice president for two terms under Ronald Reagan.


(Reporting by Kevin Gray; Editing by Daniel Trotta and Vicki Allen)


Health News Headlines – Yahoo! News





Title Post: Former President George H.W. Bush remains hospitalized
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

NRA’s LaPierre: New gun laws won't work


LaPierre speaks at Friday's press conference. (Getty)


Two days after suggesting a "good guy with a gun" be stationed at every school in the country in response to the deadly shootings in Newtown, Conn., National Rifle Association executive vice president Wayne LaPierre blasted critics of his plan.


In an interview broadcast on Sunday's "Meet The Press," LaPierre reiterated the statements he made Friday at a press conference in Washington, when he said the answer to preventing shootings like the one at Sandy Hook Elementary Sch00l is armed security in every school--in effect, protecting children with guns.


“If it’s crazy to call for putting police in and securing our schools to protect our children, then call me crazy," LaPierre said. “I think the American people think it’s crazy not to do it."


At one point during the often contentious exchange, host David Gregory held up a high-capacity magazine clip that carries 30 bullets, asking if the NRA would support a federal limit on the capacity of such clips.


"Isn't it just possible that we could reduce the carnage in a situation like Newtown?" Gregory asked.


"I don't believe that's going to make one difference," LaPierre responded.


"You're telling me that it's not a matter of common sense that if you don't have an ability to shoot off 30 rounds without reloading, that, just possibly, you could reduce the loss of life?" Gregory asked.


"I don't buy your argument for a minute," LaPierre said. "There are so many different ways to evade that, even if you had that."


“Is there no new gun regulation you would support?” an exasperated Gregory asked. LaPierre refused to answer.


At Friday's press conference, LaPierre--who did not take questions from reporters--argued that had someone at the school been armed, "innocent lives might have been spared."


"The only thing that stops a bad guy with a gun is a good guy with a gun," he said.




Read More..

NRA’s defiant LaPierre dismisses critics of school gun plan


LaPierre speaks at Friday's press conference. (Getty)


Two days after suggesting a "good guy with a gun" be stationed at every school in the country in response to the deadly shootings in Newtown, Conn., National Rifle Association executive vice president Wayne LaPierre blasted critics of his plan.


In an interview broadcast on Sunday's "Meet The Press," LaPierre reiterated the statements he made Friday at a press conference in Washington, when he said the answer to preventing shootings like the one at Sandy Hook Elementary Sch00l is armed security in every school--in effect, protecting children with guns.


“If it’s crazy to call for putting police in and securing our schools to protect our children, then call me crazy," LaPierre said. “I think the American people think it’s crazy not to do it."


At one point during the often contentious exchange, host David Gregory held up a high-capacity magazine clip that carries 30 bullets, asking if the NRA would support a federal limit on the capacity of such clips.


"Isn't it just possible that we could reduce the carnage in a situation like Newtown?" Gregory asked.


"I don't believe that's going to make one difference," LaPierre responded.


"You're telling me that it's not a matter of common sense that if you don't have an ability to shoot off 30 rounds without reloading, that, just possibly, you could reduce the loss of life?" Gregory asked.


"I don't buy your argument for a minute," LaPierre said. "There are so many different ways to evade that, even if you had that."


“Is there no new gun regulation you would support?” an exasperated Gregory asked. LaPierre refused to answer.


At Friday's press conference, LaPierre--who did not take questions from reporters--argued that had someone at the school been armed, "innocent lives might have been spared."


"The only thing that stops a bad guy with a gun is a good guy with a gun," he said.




Read More..

3-day trip becomes 3-week ordeal for 2 Jamaicans






SAN JUAN, Puerto Rico (AP) — It was supposed to be a three-day fishing trip at most. It turned into a three-week ordeal, drifting under an intense sun for hundreds of miles in the Caribbean in a small boat with a broken motor.


The two Jamaican fishermen survived by eating raw fish they caught and drinking water from melted ice they had brought to preserve their catch. The Colombian navy finally plucked them from the sea a week ago and delivered them home Saturday after treating them for severe dehydration, malnutrition and hypothermia.






Everton Gregory, 54, and John Sobah, 58, recounted their story in a telephone interview from Jamaica, while the boat owner and the men’s employer also provided details.


The men set off from Jamaica’s southeastern coast on Nov. 20. The water was glassy, the wind was calm and their boat was laden with 14 buckets of ice, 16 gallons of water and several bags of cereal, bread and fruit.


They headed to Finger Bank, a nearby sand spit 8-miles-long (13-kilometers) that is known for its abundance of fish like wahoo, tuna and mahi mahi. The owner of the 28-foot (8-meter) boat said she usually joins them on fishing trips, but she couldn’t go that afternoon.


After spending a couple of days around Finger Bank, the two men set off for home with their catch. But the boat’s engine soon died. The water was too deep to use the anchor and the current too strong to use the oars, so the boat slowly drifted away from Jamaica.


At first, the men got by on sipping the water and eating the food they brought with them. But days turned into weeks, and they began to eat the fish they had caught and drink the melted ice that had kept it fresh.


Gregory and Sobah kept eating raw fish and used a tarp to try to collect water, but the rain clouds remained at a distance.


Back home, friends and family called police and used their own boats to search the area where the men were last seen. The two fishermen work for the Florida-based nonprofit group Food for the Poor, which chartered a plane to search along Jamaica’s coast.


Marva Espuet, the owner of the boat, said she knew she had packed it with more food and water than needed for a three-day trip, but the thought provided little relief.


“If I had gone, there would have been two boats going,” said the 52-year-old woman, a longtime friend of both fishermen.


With searches proving fruitless, Sobah’s niece grew frantic, recalled Nakhle Hado, a fishing manager for Food for the Poor who helped lead the search. She “begged me that she wanted John back for Christmas,” Hado said.


Hado said some people believed the two men would never be found, but he and others didn’t give up. “My gut was telling me that they were still alive,” he said.


Hado said he had trained Gregory and Sobah on how to survive at sea.


“In case something happens, they don’t have to think twice. They know how to react,” he said. “It’s very important, their mental state.”


Gregory and Sobah finally ran out of fresh water and went several days without drink. A healthy human being can die from dehydration anywhere from three to five days without water.


Then on Dec. 12, a Colombian navy helicopter patrolling off the coast of that South American country spotted the men near Lack of Sleep cay, more than 500 miles (800 kilometers) from where they started. It took two days for a navy vessel to reach them because of bad weather. The men were hospitalized for several days at the Colombian island of San Andres before boarding a plane back home to Jamaica.


“It feels good,” Sobah told the AP in a brief phone interview after arriving.


Gregory said he had lost hope, but Sobah tried to keep him positive that they would be rescued. “I just had that belief,” Sobah said. “I believe in the Creator.”


Yet it is Gregory who plans to keep fishing despite the ordeal because he needs the job.


Sobah said he’s done. “I’m not going to go fishing again. No way.”


Latin America News Headlines – Yahoo! News





Title Post: 3-day trip becomes 3-week ordeal for 2 Jamaicans
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

“Hobbit” fever beats Tom Cruise at box office






(Reuters) – The big-budget “Hobbit” fantasy movie ruled movie box office charts for a second straight weekend, fending off Hollywood heavyweight Tom Cruise in new crime drama “Jack Reacher.”


The Hobbit: An Unexpected Journey” hauled in nearly $ 37 million from theaters in the United States and Canada, according to studio estimates of Friday-through-Sunday ticket sales. The film is the first of three movies based on the classic J.R.R. Tolkien novel about a world of dwarfs, elves and dragons in the fictitious Middle Earth.






In second place, Cruise’s “Jack Reacher” about the investigation into a sniper shooting brought in just short of $ 17 million at U.S. and Canadian theaters. Distributor Paramount Pictures postponed a premiere of the film after the fatal school shooting in Newtown, Connecticut, sparked new scrutiny of violent movies.


Adult comedy “This is 40,” starring Paul Rudd and Leslie Mann as a middle-aged couple, brought in $ 12 million, finishing in third place.


The Hobbit” was distributed by Time Warner Inc’s Warner Bros. studio. Paramount Pictures, a unit of Viacom Inc, released “Jack Reacher.” Comcast Corp’s Universal Pictures distributed “This is 40.”


(Reporting By Lisa Richwine and Andrea Burzynski)


Movies News Headlines – Yahoo! News





Title Post: “Hobbit” fever beats Tom Cruise at box office
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..